The benefits of routine-based ...
Join leading experts for this free webinar on 16 May 2023.Register
Fever in returning travellers
ISAC is pleased to announce the launch of a second free E-module which has been developed as part of a ...More info
32nd International Congress of ...
Watch the recording of Plenary 2: Treatment of multidrug resistant Pseudomonas aeruginosa infections by Prof. Juan-Pablo HorcajadaRead more
32nd International Congress of ...
Watch the recording of the opening lecture from the 32nd International Congress of Antimicrobial Chemotherapy (ICC) on "Microbial Theranostics - ...Read more
E-module: Respiratory tract infections ...
ISAC is pleased to announce the launch of its first e-module which has been created as part of the ISAC ...Read more
Deciphering the mechanisms of ...
This is the third talk in the series of webinars on "When pharmacometrics and systems pharmacology meet infectious disease" organised ...Read more
Working Group Webinars
All ISAC webinars are free to attend and free to watch after the event.
Working Group Webinars
Alliance for the Prudent Use of Antibiotics
The fight against antimicrobial resistance: a luta continua!
Expert speakers provided updates on the current AMR situation worldwide, with a particular focus on low- to middle- income countries (LMICs), and the efforts to fight it.
Prof. Pierre Tattevin / Prof. Heiman Wertheim
- Estimating the global burden of antimicrobial resistance (AMR) and how this evidence is informing new studies
Dr Catrin Moore (UK)
- Potential use of C-Reactive Protein testing to optimise community use of antibiotics
Dr Do Thi Thuy Nga (Vietnam)
- International Centre for Antimicrobial Resistance Solutions (ICARS): Partnering for impact
Dr Nandini Sreenivasan (Denmark)
- Antimicrobial resistance in Honiara, Solomon Islands
Dr Bianca Graves (Australia)
- Prevalence and drivers of over-the-counter antibiotic sales among community drug outlets to develop mitigatory behaviour change interventions
Dr Joseph Acolatse (Ghana)
- Optimised doses of polymyxins to improve outcomes for on-critically ill and critically ill patients with multidrug-resistant (MDR) Gram-negative bacterial infections
Dr Puteri Zamri (Malaysia)
Anti-Infective Pharmacology Working Group
Insights of antimicrobial therapy in biofilm-associated infections: the clinical paradigm of prosthetic joint infections
Dr Jaime Lora-Tamayo (Hospital University 12 de Octubre, Madrid, Spain) presented an overview of biofilm-associated infections by using the specific problems of prosthetic joint infections as example. Dr Lora-Tamayo focussed on the antimicrobial treatment of these infections.
New Roles of beta-lactamase enzymes
The discovery of beta-lactamase encoding sequences in different organisms and also in humans and arthropods, has opened a new field of research of their roles, since these enzymes are multi-functional and have a very ancient evolution in kingdom of life.
Jean-Marc Rolain (Editor, International Journal of Antimicrobial Agents, France) provided some examples of such discovery, including new roles of these enzymes in different fields.
Clinical Trials Targeting Antimicrobial Resistance
Antimicrobials have been a cornerstone of modern medicine. However, antimicrobial resistance is now one of the most urgent global health threats. To combat the increasing antimicrobial resistance, optimising the clinical use of current antibiotics and development of new antibiotics are critical and require robust clinical trials using pharmacokinetic/ pharmacodynamic/toxicodynamic principles.
In this ISAC online roundtable event, internationally leading clinicians and researchers reviewed the latest progress in clinical trials on antibiotics targeting antimicrobial resistance and discuss the challenges and opportunities.
Jian Li / Jaime Lora-Tomayo
- Clinical trials of new antibiotics: Innovations and challenges
- Defining antibiotic treatment duration - experience from a multicentre randomised trial in Asia
- Clinical trial networks to tackle AMR
Bone, Skin & Soft Tissue Infections Working Group
Hot topics on skin, bone and joint infections
Thank you for joining the webinar on Hot topics in skin, bone and joint infections on 24 March 2022.
The webinar covered a variety of interesting topics including mycobacterial peri-prosthetic joint infections, application of molecular assays in the diagnosis of septic arthritis, epidemiological data related to skin infections as well as timing for intravenous to oral switch in skin and soft tissue infections and antibiotic alternatives in some of these infections.
- Non tuberculosis mycobacteria and prosthetic joint infections
- Reactive Oxygen skin and soft tissue treatment
- The results of the Italian registry for SSTI, real life epidemiology and treatment of SSTI
- Detection of difficult to culture bacteria associated with bone and joint infections using real-time Polymerase Chain Reaction (PCR)
Nusreen Ahmad-Saeed (UK)
- Criteria for early switch from IV to oral antibiotics in hospitalized patients with SSTI: a prospective study
Journey into the anti-infective field: academia, clinical and industry perspectives
The ISAC Early Career Working Group and Anti-infective Pharmacology Working Group organised the first International Society of Antimicrobial Chemotherapy (ISAC) and International Society of Anti-Infective Pharmacology (ISAP) joint Early Career webinar.
This webinar aimed to provide a platform for early career researchers (ECRs) to obtain career advice and to better understand the pressures impacting them and their career development.
Dr Jinxin Zhao (Monash University / ISAC Early Career Chair)
Dr Alina Nussbaumer-Pröll (Medical University of Vienna / ISAP Secretariat
Academic speaker - Prof. Sebastian Wicha (Hamburg University)
Clinical speaker - A/Prof. Thomas Tängdén (Uppsala University, Sweden)
Industry speaker - Dr Cuong Vuong (Janssen Pharmaceuticals, Belgium)
Introduction to adaptive clinical trial design
Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trials to adjust the trials with respect to pre-specified rules. Adaptive design trials are often more efficient, informative and ethical than trials with a traditional fixed design since they often make better use of resources such as time and money and might require fewer participants.
Adaptive designs can be applied across all phases of clinical research, from early-phase dose escalation to confirmatory trials.
This talk introduced different types of adaptive designs, general principles and their key aspects. The focus is on the interpretation and reporting of results from adaptive designs through examples in literature.
This webinar is the second in the Working Group's series on "When Pharmacometrics and systems pharmacology meet infectious diseases".
Dr Amanda Wang (Speaker)
Dr Nusaibah Abdul Rahim (Moderator)
Antimicrobial Pharmacometrics: Mathematical Models for Antimicrobial Research and Development
In this talk, Dr Yu-Wei Lin introduced different antimicrobial pharmacometric techniques and highlighted the usefulness of pharmacometric analyses in antimicrobial research.
The world now faces an enormous and growing threat from the emergence of bacteria that are resistant to almost all current antibiotics. In this context, the field of pharmacometrics using mathematical models has, in recent years, emerged as an invaluable tool in academia, industry and regulatory agencies to facilitate the integration of preclinical and clinical data and to provide a scientifically based framework for designing and optimising dosing regimens.
In this talk, Dr Yu-Wei Lin will introduce different antimicrobial pharmacometric techniques and highlight the usefulness of pharmacometric analyses in antimicrobial research.
Dr Yu-Wei Lin (Speaker)
Dr Jinxin Zhao (Moderator)
ICU & Sepsis Working Group
Hot topics on infections in critical care
Infections represent a major cause of morbidity and mortality in the critical care setting, especially in our era of multidrug-resistant pathogens.
During the COVID19 pandemic, on the other hand, a significant increase in the prevalence of ICU infections has been reported. Prompt diagnosis of critical care infections and appropriate treatment in optimised doses, along with antibiotic stewardship, are of outmost importance for improved outcomes and tackling antimicrobial resistance development.
- Diagnosis and management of severe community-acquired pneumonia
- Diagnosis and management of abdominal sepsis
Jan De Waele
- Management of infections caused by MDR Gram-negative pathogens
- Management of S.aureus bacteremia
- Viral infections in the Intensive Care Unit
- Role of biomarkers for sepsis diagnosis in critically ill patients
- Antibiotic de-escalation
Liesbet De Bu
- Antibiotic stewardship (in COVID-19 era)
- Therapeutic Drug Monitoring and antibiotic optimization in the Intensive Care Unit
- Host-targeted immunotherapies in the Intensive Care Unit
- COVID-19 in haematological malignancies: outcome of infection and the effects of vaccination
- Ventilator associated pneumonia in COVID-19 patients
Andrew Conway Morris
- Management of severe COVID19 infection
MRSA Working Group
Regional & National MRSA Surveillance Programmes Worldwide
The webinar aimed to review national and regional surveillance programmes for Methicillin-Resistant Staphylococcus aureus (MRSA).
The first meeting included brief presentations from laboratories in several countries that undertake MRSA surveillance. This was followed by a period of moderated discussion to assess best practices. The goals were to understand the variety of approaches to surveillance worldwide and to develop principles that may underlie future harmonization of surveillance methods.
Margreet Vos / Valerie Baede / Michael Z. David
Regional & National MRSA Surveillance Programs: results of a survey
Short laboratory presentations from the following speakers:
- Harald Seifert (University of Cologne, Germany)
- Anders Rhod Larsen (Statens Serum Institut, Copenhagen)
- Guido Werner (Robert Koch Institute, Wernigerode)
- Leo Schouls (Centre for Infectious Disease Control Netherlands (CIb), National Institute for Public Health and the Environment, the Netherlands)
- Joanna Empel (National Medicines Institute, Warsaw, Poland)
- Michael Borg (Mater Dei Hospital, Malta)
- Domnique Blanc (Lausanne University Hospital,, Switzerland)
- Boudewijn Catry (Sciensano, Belgium)
- Helena Žemličková (National Institute of Public Health, Czech republic)
- Aurélie Chabaud (Limoges University Hospital, France)
- Francois Vandenesch (National Reference Center for Staphylococc, France)
Rapid Diagnostics & Biomarkers Working Group
Rapid diagnostics & biomarkers at the heart of patient management
Provision of medicine is transforming due to the amount of research and development in novel diagnostics and technologies.
In this webinar, ISAC’s Rapid Diagnostics & Biomarkers Working Group provided a number of short presentations on how rapid and novel diagnostics and technologies and their application can impact clinical practice and the provision of microbiology, infectious disease, antimicrobial stewardship and infection control services.
Kordo Saeed (University Hospitals Southampton NHS Foundation Trust, UK)
- Role of PCT in COVID-19 Patients
Eric Howard Gluck (Swedish Hospital, USA)
- Rapid pneumonia diagnostics in the molecular age: results from the SARIPOC trial
Stephen Poole (Biomedical Research Centre, UK)
- Is proinflammatory biomarker ProADM helpful for risk stratification in COVID-19 patients?
Philipp Schuetz (Kantonsspital Aarau, Switzerland)
- QiaSTAT and patient safety: experiences with a rapid PCR system
Peter Laszlo Kanizsai (University of Pécs, Hungary)
- Rapid biomarkers in community setting to improve antibiotic use
Heiman Wertheim (the Netherlands)
Dissemination of viral infections during mass gatherings
The purpose of this webinar was to outline the most significant viral infections currently associated with mass gatherings, suggest key planning considerations for the organisers of mass gatherings in the context of novel viral outbreaks and provide general advice on the public health aspects of mass events.
Moderator: Prof. Fatma Amer (Chair of ISAC's Viral Infections Working Group)
1. Respiratory-borne viral infections during mass gatherings
Prof. Jaffar A. Al-Tawfiq
2. Monkeypox virus: is it the coming challenge during mass gatherings?
Prof. Alfonso J. Rodriguez-Morales
3. Water- and food- borne viral infections during mass gatherings
Dr Anusha Rohit
4. Vector-borne viral infections during mass gatherings
Dr Rehab Tash
Monkeypox: a new human threat?
Experts provided the latest information on the epidemiology, transmission, diagnosis, prevention and treatment of monkeypox and ISAC's recent webinar which was organised by the Viral Infections Working Group.
Chair: Prof.Fatma Amer
- Immunology and virology - Dr Noha Hammad
- Transmission dynamics - Dr Kalisvar Marimuthu
- Clinical aspects of monkeypox - Prof. Souha Kanj
- Ongoing epidemiology of monkeypox - Prof. Alfonso Rodriquez-Morales
- Infection prevention and control of monkeypox - Dr Rehab Tash